Histopathological examination of Buruli ulcer (<i>Mycobacterium ulcerans</i> disease) in surgically removed skin

DOI PubMed 14 References Open Access
  • WAKAI Satoyo
    Division of Research and Examination, National Hospital Organization Nishisaitama-Chuo National Hospital
  • YAJIMA Mikihisa
    Division of Research and Examination, National Leprosarium Tama Zenshoen

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  • ブルーリ潰瘍（Buruli ulcer, <i>Mycobacterium ulcerans</i> disease）の切除皮膚における病理組織学的検討
  • Histopathological examination of Buruli ulcer (Mycobacterium ulcerans disease) in surgically removed skin

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We report the results of an examination of gross images of two patients with Buruli ulcer and a histopathological evaluation of surgically removed skin from two other cases at the non-ulcerated and ulcerated stages, respectively. Histopathologically, dermal nodes were found in the non-ulcerated specimen; while wide necrosis of skin and fibrin deposition, as well as Langhans giant cell, epitheloid cells, and vasculitis, were observed in the ulcerated specimen, with granuloma in the lymph nodes. M.ulcerans was positive in a Fite stain and in a PGL-1 immunohistological stain. Based on these cases, we discuss the histological characteristics of Buruli ulcer.

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