Hepatic Content of Coenzyme Q in Rats After Administration of Various Coenzyme Q Compounds and <sup>14</sup>C-Labeled Coenzyme Q<sub>7</sub>

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  • SHIGETA YUKIO
    First Department of Internal Medicine, Osaka University Medical School
  • IZUMI KANJI
    First Department of Internal Medicine, Osaka University Medical School
  • ABE HIROSHI
    First Department of Internal Medicine, Osaka University Medical School

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  • Hepatic content of coenzyme Q in rats after administration of various coenzyme Q compounds and 14C-labeled coenzyme Qr
  • Hepatic Content of Coenzyme Q in Rats After Administration of Various Coenzyme Q Compounds and 14C-Labeled Coenzyme Q7

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Abstract

1. The CoQ content of whole rat liver increased significantly as compared with the control after the intramuscular administration of CoQ7, CoQ9 or CoQ10, but increased slightly after the administration of CoQ2 or CoQ6. In the mitochondrial fraction, CoQ content increased only after the administration of CoQ7 or CoQ9. After the administration of CoQ compounds, paper chromatography of the liver extract showed a corresponding increase of CoQ.<br>2. Twenty-four hours after giving CoQ7-14C to rats, the percentage recovery in the liver administered was found to be 12.3±0.47% of the dose of 14C administered intramuscularly or 11.8±1.37% of those given orally. When the CoQ fraction was developed paperchromatographically, the radioactivity on the actigram was found in the CoQ7 portion exclusively.

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