Urinary Aspartate Transaminase in Childhood

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  • 長谷川 豊
    Department of Pediatrics, School of Medicine, Tokushima University
  • 宮尾 益英
    Department of Pediatrics, School of Medicine, Tokushima University
  • 北村 義男
    Department of Pediatrics, School of Medicine, Tokushima University
  • 松沢 健夫
    Department of Enzyme Chemistry, Institute for Enzyme Research, School of Medicine, Tokushima University
  • 勝沼 信彦
    Department of Enzyme Chemistry, Institute for Enzyme Research, School of Medicine, Tokushima University

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Urinary aspartate transaminase in normal children and children with various renal diseases including orthostatic proteinuria were determined. The mean values of urinary aspartate transaminase activities in healthy, nephrotic, acute nephritic and orthostatic proteinuric children were found to be 12.9±7.2, 53.0±38.4, 115.8±66.6 and 100.3±63.4μmoles oxaloacetate formed per hour in 24-hour urine, respectively.<br>In orthostatic proteinuria, the enzyme level in urine together with urinary protein excretion was almost equal to ther values obtained from nephritic children. On the basis of these observations, a possible pathogenesis of orthostatic proteinuria was discussed.<br>Determination of urinary aspartate transaminase activity was found to be of use for the differential diagnosis of renal diseases. An isoenzyme nature of urinary transaminase was also studied.

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