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- 吉野 俊昭
- The First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
書誌事項
- タイトル別名
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- The Clinical and Experimental Studies on the Metabolism of Folic Acid Using Tritiated Folic Acid
- I. Absorption Tests of Tritiated Folic Acid in Man
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説明
1. The absorption tests of tritiated folic acid (3H-FA) and 60Co-cyanocobalamin (60Co-B12) were carried out in normal subjects and patients with gastrointestinal or hematological diseases.<br>2. An oral dose of 40μg 3H-FA per kg of body weight was given 30 minutes after an injection of 15mg of non-radioactive FA. The urinary excretion of 3H-FA was estimated in following 24 hours. In some cases the fecal excretion of 3H-FA was measured for successive four days.<br>3. The urinary excretion of 3H-FA in eleven normal subjects ranged from 37.6 to 57.9 per cent of the oral dose, with a mean of 48.4 per cent and a standard deviation of 7.4 per cent. The fecal excretion ranged from 1.5 to 7.5 per cent of the dose with a mean of 3.5 per cent and a standard deviation of 3.5 per cent.<br>4. In some cases of gastrectomy, defective FA absorption was observed.<br>5. Decreased urinary excretion was found in patients with blind loop syndrome and also in some case of ileocolostomy.<br>6. Urinary excretion of 3H-FA was diminished in some cases of hematological disorders, such as pernicious anemia and leukemia.<br>7. The causes of defective FA absorption were discussed in each case.
収録刊行物
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- THE JOURNAL OF VITAMINOLOGY
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THE JOURNAL OF VITAMINOLOGY 14 (1), 21-34, 1968
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001206323244160
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- NII論文ID
- 130001748989
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- NII書誌ID
- AA00247734
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- COI
- 1:CAS:528:DyaF1cXhtFalsr4%3D
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- NDL書誌ID
- 8506091
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- ISSN
- 00225398
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- PubMed
- 5674428
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可