Absorption tests of tritiated folic acid in man

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  • 吉野 俊昭
    The First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

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  • The Clinical and Experimental Studies on the Metabolism of Folic Acid Using Tritiated Folic Acid
  • I. Absorption Tests of Tritiated Folic Acid in Man

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1. The absorption tests of tritiated folic acid (3H-FA) and 60Co-cyanocobalamin (60Co-B12) were carried out in normal subjects and patients with gastrointestinal or hematological diseases.<br>2. An oral dose of 40μg 3H-FA per kg of body weight was given 30 minutes after an injection of 15mg of non-radioactive FA. The urinary excretion of 3H-FA was estimated in following 24 hours. In some cases the fecal excretion of 3H-FA was measured for successive four days.<br>3. The urinary excretion of 3H-FA in eleven normal subjects ranged from 37.6 to 57.9 per cent of the oral dose, with a mean of 48.4 per cent and a standard deviation of 7.4 per cent. The fecal excretion ranged from 1.5 to 7.5 per cent of the dose with a mean of 3.5 per cent and a standard deviation of 3.5 per cent.<br>4. In some cases of gastrectomy, defective FA absorption was observed.<br>5. Decreased urinary excretion was found in patients with blind loop syndrome and also in some case of ileocolostomy.<br>6. Urinary excretion of 3H-FA was diminished in some cases of hematological disorders, such as pernicious anemia and leukemia.<br>7. The causes of defective FA absorption were discussed in each case.

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