Acute Toxicity and Mutagenicity Study on Branched Corn Syrup and Evaluation of Its Laxative Effect in Humans.
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- KISHIMOTO Yuka
- Research Institute, Matsutani Chemical Industry Company Ltd.
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- WAKABAYASHI Shigeru
- Research Institute, Matsutani Chemical Industry Company Ltd.
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- MATSUDA Isao
- Research Institute, Matsutani Chemical Industry Company Ltd.
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- FUDABA Hiroaki
- Research Institute, Matsutani Chemical Industry Company Ltd.
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- OHKUMA Kazuhiro
- Research Institute, Matsutani Chemical Industry Company Ltd.
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We developed a branched corn syrup (BCS, average molecular weight: 500, content of indigestible portion: 45%) by heat treatment of indigestible dextrin with hy-drochloric acid. To confirm the safety of BCS, we conducted both an acute toxicity test and a mutagenicity test. Moreover, we observed gastroenteric effects of BCS in fifty healthy hu-mans. The results are summarized as follows. l) There was no death observed after oral ad-ministration of BCS in Sprague-Dawley-strain rats. Lethal dose (LD)50 value was estimated to be more than 10 g/kg body weight. 2) No mutagenicity was observed in Salmonella typhimurium TA98, TA100, TA1535, TA1537, or Escherichia coli WP2uvrA. 3) Fifty adults were divided into five groups of ten (five of each sex) and orally administered BCS at 0.2, 0.3, 0.4, 0.5 and 0.6 g/kg body weight as indigestible portion. Although no diarrhea was ob-served in females, BCS at 0.6 g/kg as indigestible portion caused diarrhea in two out of five males. The maximum non-effective dose of indigestible portion of BCS was estimated to be 0.5 g/kg in males and more than 0.6 g/kg in females.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 47 (2), 126-131, 2001
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詳細情報 詳細情報について
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- CRID
- 1390001206323368960
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- NII論文ID
- 10010805489
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 5798749
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- PubMed
- 11508703
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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- 使用不可