<i>Lmx-1b</i> and <i>Wnt-7a</i> expression in axolotl limb during development and regeneration

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  • Lmx-1b and Wnt-7a expression in axolotl limb during development and regeneration

Abstract

Axolotls (Ambystoma mexicanum) have the ability to regenerate amputated limbs throughout their life span. During limb regeneration as well as development, undifferentiated cells in the blastema acquire positional information to reproduce the original pattern along three cardinal limb axes: anteroposterior, proximodistal and dorsoventral. In the present study, we attempted to understand the molecular mechanism involved in patterning of axolotl limb development and regeneration along the dorsoventral (DV) axis. We cloned axolotl Lmx-1b and Wnt-7a, and investigated the expression pattern of these genes in developing and regenerating limbs. In axolotl, unlike in amniotes, Wnt-7a was expressed in a diffuse manner throughout both developing limb bud and regenerating limb blastema. Lmx-1b expression was observed at the dorsal mesenchyme in the developing and regenerating limbs. On the basis of the expression patterns of Lmx-1b and Wnt-7a, it was difficult to identify the interaction between these two genes as reported in amniotes in previous studies. Possibly, with regard to Lmx-1b expression, a Wnt-7a-independent mechanism may exist in axolotl limb development and regeneration.

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Details 詳細情報について

  • CRID
    1390001206323472896
  • NII Article ID
    130004495117
  • DOI
    10.2535/ofaj.89.119
  • COI
    1:STN:280:DC%2BC3srot1Sqtw%3D%3D
  • ISSN
    18811736
    0030154X
  • PubMed
    23614984
  • Text Lang
    en
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • KAKEN
  • Abstract License Flag
    Disallowed

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