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Metabolic conversion of cyclocarbothiamine into thiamine was studied in vivo as well as in vitro.<br>1. The compound was easily transformed into thiamine when incubated with rabbit blood.<br>The supernatant obtained from liver and kidney homogenate of rats also changed cyclocarbothiamine into thiamine. No such conversion occurred with heated supernatant.<br>2. Manometric measurement of carbon dioxide liberated during the conversion showed that it was produced in an amount equimolar to thiamine.<br>3. Bioautography with Lactobacillus fermenti revealed that not a trace of cyclocarbothiamine remained unchanged in blood samples taken 30 minutes after oral or intravenous administration to rabbits. Nor was it detected as such in urine.<br>However, a trace amount of the compound was detected unaltered in threehour urine samples following oral administration of 50mg to human subjects.<br>4. The following metabolic schema has been established.<br>Cyclocarbothiamine → Thiamine+CO2
収録刊行物
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- THE JOURNAL OF VITAMINOLOGY
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THE JOURNAL OF VITAMINOLOGY 13 (2), 145-151, 1967
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詳細情報 詳細情報について
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- CRID
- 1390001206323685248
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- NII論文ID
- 130001748859
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- NII書誌ID
- AA00247734
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- COI
- 1:CAS:528:DyaF2sXksFWlsLw%3D
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- NDL書誌ID
- 8506058
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- ISSN
- 00225398
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- PubMed
- 6053377
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可