Peripheral Vitamin C Levels in Alzheimer’s Disease: A Cross-Sectional Study
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- IDE Kazuki
- Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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- YAMADA Hiroshi
- Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka Department of Neurology, Shizuoka General Hospital
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- KAWASAKI Yohei
- Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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- YAMANAKA Mie
- Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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- KAWAKAMI Nobuko
- Department of Neurology, Shizuoka General Hospital
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- KATSUYAMA Yusuke
- Department of Neurology, Shizuoka General Hospital
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- YOSHIDA Hidefumi
- Department of Neurology, Shizuoka General Hospital
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- KIM Kang
- Department of Neurology, Shizuoka General Hospital
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- SHIOSAKI Emi
- Department of Clinical Laboratory Medicine, Shizuoka General Hospital
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- SONODA Akihiro
- Department of Clinical Laboratory Medicine, Shizuoka General Hospital
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- UMEGAKI Keizo
- Information Center, National Institutes of Biomedical Innovation, Health and Nutrition
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- HARADA Kiyoshi
- Department of Neurology, Shizuoka General Hospital
書誌事項
- タイトル別名
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- Peripheral Vitamin C Levels in Alzheimer’s Disease: A Cross-Sectional Study
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We previously reported lower lymphocyte vitamin C levels in individuals with type 2 diabetes mellitus and in individuals with severe Parkinson’s disease. Oxidative stress has been proposed to play a key role in the progression of Alzheimer’s disease. Thus, the objective of this study was to investigate the association between peripheral levels of vitamin C and the progression of cognitive dysfunction in Alzheimer’s disease. Fifty individuals with Alzheimer’s disease being treated at Shizuoka General Hospital were consecutively enrolled in this study from December 2009 to March 2015 (76.0±9.7 y of age [mean±SD]; 32 men and 18 women; Mini-Mental State Examination Japanese version (MMSE-J) score range, 8-27). Plasma and lymphocyte vitamin C levels in fasting blood samples were measured. The association between the MMSE-J scores and vitamin C levels was estimated using Spearman’s rank correlation coefficient (ρ) and the criteria defined by Swinscow. Spearman’s ρ for the relationship between peripheral vitamin C levels and the MMSE-J score was ρ=0.17 for plasma vitamin C and ρ=0.26 for lymphocyte vitamin C. Thus, the associations were relatively weak based on the criteria. In contrast with type 2 diabetes mellitus and Parkinson’s disease, lymphocyte vitamin C levels in the peripheral blood may not directly reflect the progression of cognitive dysfunction in Alzheimer’s disease. Additional longitudinal studies are needed to evaluate the clinical importance of changes of peripheral vitamin C status in Alzheimer’s disease.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 62 (6), 432-436, 2016
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詳細情報 詳細情報について
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- CRID
- 1390001206323837056
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- NII論文ID
- 130005332251
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 027809918
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- PubMed
- 28202849
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可