Effects of Pediococcus acidilactici R037 on Serum Triglyceride Levels in Mice and Rats after Oral Administration
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- UEDA Takahiro
- Nutrition Strategic Unit, Kaneka Corporation
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- TATEGAKI Airo
- Health Care Solutions Research Institute, Kaneka Corporation
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- HAMADA Kazuya
- Medical Devices Solutions Vehicle, Kaneka Corporation
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- KISHIDA Hideyuki
- Health Care Solutions Research Institute, Kaneka Corporation
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- HOSOE Kazunori
- Pharma & Supplemental Nutrition Solutions Vehicle, Kaneka Corporation
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- MORIKAWA Hideyuki
- Pharma & Supplemental Nutrition Solutions Vehicle, Kaneka Corporation
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- NAKAGAWA Kaku
- Nutrition Strategic Unit, Kaneka Corporation
書誌事項
- タイトル別名
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- Effects of <i>Pediococcus acidilactici</i> R037 on Serum Triglyceride Levels in Mice and Rats after Oral Administration
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抄録
The biological effects of heat-killed Pediococcus acidilactici R037 (R037) were evaluated when orally administered in mice and rats. Oral R037 administration at a daily dose of 10 and 100 mg/kg for 3 wk dose-dependently reduced fasting and non-fasting serum triglyceride concentrations in KK-Ay/TaJcl mice, a model of type II diabetes, obesity, hypercholesterolemia, and hypertriglyceridemia. Serum levels of free fatty acids in the 100 mg/kg group tended to decrease (not statistically significant), and total cholesterol levels remained unchanged. Treatment with R037 resulted in a significant decrease in blood glucose (at 100 mg/kg) and liver weight (at 10 and 100 mg/kg), and a small body weight gain (at 100 mg/kg) as compared to those in control mice. In addition, oral R037 administration at 100, 200, and 400 mg/kg/d for 1 wk dose-dependently suppressed the increase in serum triglyceride levels in Wistar rats after oral fat loading. Moreover, intraduodenal injection of 120 mg of R037 in Wistar rats suppressed gastric vagal nerve activity (GVNA) indicating suppression of intestinal digestion and absorption of food, and suppression of appetite. The R037 injection potentiated epididymal white adipose tissue sympathetic nerve activity (WAT-SNA) and tended to potentiate pancreatic sympathetic nerve activity (PSNA), suggesting that R037 activated lipolysis. Taken together, these findings indicate that R037 lowers serum triglycerides, possibly through suppressing intestinal absorption and potentiating lipolytic pathways. R037 may be useful for primary prevention of coronary artery diseases in subjects with mild or borderline dyslipidemia in combination with lifestyle changes.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 64 (1), 41-47, 2018
一般財団法人 学会誌刊行センター
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詳細情報 詳細情報について
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- CRID
- 1390001206323967744
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- NII論文ID
- 130006405219
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 029130246
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- PubMed
- 29491271
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可