[6]-Gingerol Induces Electrogenic Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1

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  • TSUCHIYA Yo
    Department of Living Science, Faculty of Home Economics, Tohoku Women’s College
  • FUJITA Rina
    Department of Living Science, Faculty of Home Economics, Tohoku Women’s College
  • SAITOU Akae
    Department of Living Science, Faculty of Home Economics, Tohoku Women’s College
  • WAJIMA Nanako
    Department of Living Science, Faculty of Home Economics, Tohoku Women’s College
  • AIZAWA Fuyuka
    Department of Living Science, Faculty of Home Economics, Tohoku Women’s College
  • IINUMA Akane
    Department of Living Science, Faculty of Home Economics, Tohoku Women’s College

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[6]-Gingerol possesses a variety of beneficial pharmacological and therapeutic properties, including anti-carcinogenic, anti-inflammatory, and anti-emetic activities. Although [6]-gingerol is known to regulate the contraction of the intestine, its effect on intestinal ion transport is unclear. The aim of this study was to examine the role of [6]-gingerol in the regulation of electrogenic ion transport in the rat intestine by measuring the transmural potential difference (ΔPD). [6]-Gingerol induced significant positive ΔPD when administered to the serosal but not mucosal side of the colon, ileum, and jejunum; the highest effect was detected in the colon at a concentration of 10 μM. [6]-Gingerol-induced increase in ΔPD was suppressed by ouabain, an inhibitor of Na+/K+-ATPase, whereas no effect was observed in response to bumetanide, an inhibitor of the Na+-K+-2Cl− co-transporter. In addition, ΔPD induction by [6]-gingerol was greatly diminished by capsazepine, an inhibitor of the capsaicin receptor TRPV1. These results suggest that [6]-gingerol induced the electrogenic absorption of sodium in the rat colon via TRPV1.

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