Teratogenesis of the Horseshoe Crab by α-Lipoic Amide(6,8-Thioctic Amide) in Marketed Vitamin Tablets

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  • 伊藤 富夫
    Department of Biology, Faculty of Education, Shizuoka University

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  • Teratogenesis of the horseshoe crab by .ALPHA.-lipoic amide (6,8-thioctic amide) in marketed vitamin tablets.
  • Teratogenesis of the Horseshoe Crab by

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Some marketed vitamin tablets induce defects and fusion of body segments and appendages in the developing horseshoe crab.<br> α-Lipoic amide may be responsible for the induction, and the other vitamins are probably not directly responsible. α-Lipoic acid also induces the same malformations.<br> It is presumed that α-Lipoic amide and α-lipoic acid inhibit thioldisulphide exchange and this inhibition disturbs the morphogenetic movement. As a result, the monsters may be induced by treatment with vitamin tablets.

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