Demonstration of a novel molecular species in chick embryo brain: Cellular retinol-binding protein, F-type.
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- 佐藤 真由美
- Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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- 大森 正英
- Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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- 武藤 泰敏
- Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo The First Department of Internal Medicine, Gifu University School of Medicine
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- タイトル別名
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- Demonstration of a novel molecular spec
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By sucrose density gradient sedimentation analysis, a cytosol component of small molecular size which bound 3H-retinoic acid was detected in the chick embryo brain, exhibiting a peak on day 14 (7 days before hatching). In general, cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP) have been distin-guished by showing binding specificity for retinol or retinoic acid, respectively. However, the component found in embryo brain cytosol exhibited binding affinity for both retinol and retinoic acid, being similar in less ligand-specificity to CRBP (F) which was originally recognized in fish eye cytosol. Moreover, the component also showed a lack of binding affinity for prealbumin (PA), excluding the possibility that chicken plasma RBP was contaminated in the cytosol. These findings strongly suggest that a distinct molecular species of cellular binding protein for vitamin A exists in the brain cytosol of a developing chick embryo.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 25 (1), 1-7, 1979
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詳細情報 詳細情報について
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- CRID
- 1390001206324375424
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- NII論文ID
- 130001372018
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 2079741
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- PubMed
- 571904
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可