Inhibitory Effects of Wasabi Isothiocyanates on Chemical Mediator Release in RBL-2H3 Rat Basophilic Leukemia Cells
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- YAMADA-KATO Tomoe
- KInjirushi Co., Ltd.
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- NAGAI Masashi
- KInjirushi Co., Ltd.
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- OHNISHI Motoko
- Department of Biological Chemistry, College of Bioscience and Biotechnology, Chubu University
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- YOSHIDA Kazutoshi
- Hyogo Prefectural Institute of Technology
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抄録
Wasabi is a plant of Japanese origin. It belongs to the family Brassicaceae and produces various isothiocyanates (ITCs). To clarify the type I allergies inhibited by wasabi ITCs, we investigated the inhibitory effect on chemical mediator release from dinitrophenylated bovine serum albumin (DNP-BSA)-stimulated RBL-2H3 rat basophilic leukemia cells. Allyl ITC (AITC), sec-butyl ITC (s-BuITC), and 3-butenyl ITC (3-BuITC), which have 3 or 4 carbon chains, inhibited histamine release but did not inhibit the release of leukotriene B4 (LTB4) or cysteinyl LTs (CysLTs). 4-Pentenyl ITC (4-PeITC) and 5-hexenyl ITC (5-HeITC), which have 5 or 6 carbon chains and an unsaturated bond at the end, inhibited LTB4 release but did not inhibit the release of histamine or CysLTs. 6-Methylthiohexyl ITC (6-MTITC), 6-methylsulfinylhexyl ITC (6-MSITC), and 6-methylsulfonylhexyl ITC (6-MSFITC), which have a sulfur atom inserted at the end of a 6-carbon chain, inhibited the release of histamine, LTB4, and CysLTs and the elevation in intracellular Ca2+. These results suggest that wasabi ITCs inhibited type I allergies by inhibiting chemical mediator release and that the inhibitory effects on each chemical mediator were due to differences in the side chain structure of the wasabi ITCs.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 58 (4), 303-307, 2012
一般財団法人 学会誌刊行センター
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詳細情報 詳細情報について
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- CRID
- 1390001206324549760
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- NII論文ID
- 130002103023
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC38Xhtlems77L
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 023900341
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- PubMed
- 23132316
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可