Bradycardia in thiamin deficiency and the role of glyoxylate.

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  • Bradycardia in thiamin deficiency and t

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1. Method of recording the heart rate in rats is described.<br> 2. It was found that during the course of developing thiamin deficiency, the heart rate of rats dropped from 448 to 220 beats/min. (There was no difference between male and female rats.)<br> 3. A number of metabolic products were injected into the normal rats and only glyoxylate was shown to cause a significant drop in heart rate.<br> 4. Graded amounts of Na-glyoxylate were injected peritoneally into the normal rats and blood samples were taken at intervals to test the amount of glyoxylate present. It was found that peak concentra-tion appeared 6min after injection and thereafter declined or disappeared, depending on the amount of glyoxylate administered.<br> 5. It was found that glyoxylate accumulates in the body of thiamin-deficient rats and in the pair-fed rats reared on restricted diet for a long period.<br> 6. Drop in heart rate depended on the appearance of glyoxylic acid present in the blood rather than on the reduction of body weight.

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