Insights on Vitamin D's Role in Cardiovascular Disease: Investigating the Association of 25-Hydroxyvitamin D with the Dimethylated Arginines
-
- A. ABU EL MAATY Mohamed
- Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo
-
- I. HASSANEIN Sally
- Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo
-
- S. HANAFI Rasha
- Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo
-
- Z. GAD Mohamed
- Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo
この論文をさがす
抄録
Accumulating evidence has stipulated a strong correlation between vitamin D (vitD) deficiency and cardiovascular disease (CVD); however, a mechanistic link is missing. This study investigated the association of vitD with endothelial dysfunction parameters. Subjects comprised male patients with verified coronary artery disease (CAD) (n=69) and age- and sex-matched controls (n=20). 25-Hydroxyvitamin D [25(OH)D] was determined using high performance liquid chromatography with ultraviolet detection whereas asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively) were determined by liquid chromatography-mass spectrometry. Nitric oxide (NO) was determined spectrophotometrically and high-sensitivity C-reactive protein (hs-CRP) was determined using enzyme-linked immunosorbent assay (ELISA). Comparison of mean 25(OH)D concentrations of patients and controls yielded a significant result (p=0.0002). 25(OH)D2 was dominant in patients whereas 25(OH)D3 was dominant in controls (p=0.003 and 0.001, respectively). Comparison of mean ADMA and SDMA concentrations of patients exhibiting normal and suboptimal vitD yielded insignificant results (p=0.692 and 0.998, respectively). Significant results were obtained from the comparison of mean hs-CRP and NO concentrations of patients exhibiting normal and suboptimal vitD (p=0.035 and 0.031, respectively). Results suggest involvement of vitD with the NO system, however not via modulation of the dimethylated arginines. A potential anti-inflammatory activity for vitD is also raised.
収録刊行物
-
- Journal of Nutritional Science and Vitaminology
-
Journal of Nutritional Science and Vitaminology 59 (3), 172-177, 2013
一般財団法人 学会誌刊行センター
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206324814208
-
- NII論文ID
- 130003368167
-
- NII書誌ID
- AA00703822
-
- COI
- 1:CAS:528:DC%2BC3sXhtFaksrrL
-
- ISSN
- 18817742
- 03014800
-
- NDL書誌ID
- 024644155
-
- PubMed
- 23883687
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可