Influences of Maternal B₁₂ and Methionine Intake during Gestation and Lactation on Testicular Development of Offspring in Rats

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  • YAMADA Kazuhiro
    Department of Applied Biology and Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture
  • MAEDA Nozomi
    Division of Life, Health, and Sports Education, Graduate School of Education, Okayama University
  • NOGUCHI Junko
    Animal Development and Differentiation Research Unit, Division of Animal Science, National Institute of Agrobiological Sciences
  • YAMADA Hideaki
    Department of Nursery, Fukushima College
  • MORINAGA Emi
    Division of Life, Health, and Sports Education, Graduate School of Education, Okayama University
  • YATAKE Hitomi
    Division of Life, Health, and Sports Education, Graduate School of Education, Okayama University
  • YAMAMOTO Yuji
    Department of Applied Biology and Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture
  • TADOKORO Tadahiro
    Department of Applied Biology and Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture
  • KAWATA Tetsunori
    Division of Life, Health, and Sports Education, Graduate School of Education, Okayama University

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タイトル別名
  • Influences of Maternal B<sub>12</sub> and Methionine Intake during Gestation and Lactation on Testicular Development of Offspring in Rats

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The influence of maternal vitamin B12 malnutrition on testicular development of offspring was examined using soy protein-based B12-deficient diets with or without 0.5% DL-methionine supplementation. Dams were fed the B12-deficient diet throughout gestation and lactation, whereas dams in a control group were fed a control diet which contained cyanocobalamin in the B12-deficient diet without methionine. Offspring born to dams fed the B12-deficient diet without methionine showed poor testicular development, e.g. decreased numbers of seminiferous tubules containing healthy spermatocytes and a high ratio of apoptotic cells per all germ cells. The abnormality was rarely observed in the group fed the B12-deficient diet with methionine. It was likely that the testicular abnormality of offspring was caused by B12-deficiency post partum and was prevented by the methionine supplementation. These observations suggested that maternal B12 nutritional status during the pre-weaning period is quite important for spermatogenesis of male offspring and that the requirement of B12 for testicular development is to produce active B12-dependent methionine synthase.

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