Lactobacillus crispatus KT-11 Enhances Intestinal Immune Functions in C3H/HeN Mice
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- TOBITA Keisuke
- Interdisciplinary Graduate School of Science and Technology, Shinshu University Kitii Co., Ltd.
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- YANAKA Hiroyuki
- Kitii Co., Ltd.
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- OTANI Hajime
- Interdisciplinary Graduate School of Science and Technology, Shinshu University
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We investigated the effect of Lactobacillus crispatus KT-11 (KT-11) on intestinal immune systems in C3H/HeN mice. The level of intestinal total immunoglobulin (Ig) A was significantly higher in mice given KT-11 than in mice not given KT-11. Gene expression relating to antibody production and innate immune response increased more than 2-fold in the former compared with the later. Moreover, the number of IL-6+CD11b+ cells was significantly higher in Peyer's patch cells cultured with KT-11 than in those cultured without KT-11, although the number of CD4+ cells and the cell ratio of CD4+/CD8+ were remarkably lower in the culture with KT-11. These results indicate that KT-11 enhances intestinal IgA production and innate immune response in C3H/HeN mice.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｎｕｔｒｉｔｉｏｎａｌ Ｓｃｉｅｎｃｅ ａｎｄ Ｖｉｔａｍｉｎｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｎｕｔｒｉｔｉｏｎａｌ Ｓｃｉｅｎｃｅ ａｎｄ Ｖｉｔａｍｉｎｏｌｏｇｙ 56 (6), 441-445, 2010
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詳細情報 詳細情報について
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- CRID
- 1390001206324867456
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- NII論文ID
- 10027415536
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC3MXhtV2qsb8%3D
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- ISSN
- 18817742
- 03014800
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- HANDLE
- 10091/13189
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- NDL書誌ID
- 10933143
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- PubMed
- 21422714
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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