Relationship between accumulation of guanine ribonucleotidyl-(3′-5′)-adenosine and formation of riboflavin
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- 満田 久輝
- Laboratory of Nutritional Chemistry, Faculty of Agriculture, Kyoto University Faculty of Nutrition, Koshien University
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- 西川 善之
- Laboratory of Nutritional Chemistry, Faculty of Agriculture, Kyoto University Faculty of Nutrition, Koshien University
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- 中島 謙二
- Laboratory of Nutritional Chemistry, Faculty of Agriculture, Kyoto University
書誌事項
- タイトル別名
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- Relationship between accumulation of guanine ribonucleotidyl-(3'-5')-adenosine and formation of riboflavin.
- Relationship between accumulation of gu
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抄録
The possibility whether guanine ribonucleotidyl-(3'-5')-adenosine (GpA) is accumulated or not was studied with the use of micro-organisms such as E. ashbyii (a non-flavinogenic strain), E. coil, S. cerevisiae and N. crassa, which produce riboflavin in a trace amount. (1) In a flavinogenic strain of E. ashbyii, riboflavin formation was stimulated fivefold in the presence of glucose (1%) compared with that in the control experiment without glucose. The presence of caffeine notice-ably restricted riboflavin formation during incubation of non-growing cells with or without glucose. Moreover, the addition of caffeine to the glucose-free medium brought about marked accumulation of GpA in the cells.<br> (2) In a non-flavinogenic strain of E. ashbyii, riboflavin formation was remarkably slight under normal conditions. The effect of glucose and caf-feine on flavinogenesis in the same strain was much smaller than that in the flavinogenic strain except for the case of the glucose-free medium supple-mented with caffeine. However, compound (GpA) never accumulated in the strain, even under conditions permitting a large amount accumulation of GpA in a flavinogenic strain.<br> (3) The other organisms, E. coil, S. cerevisiae and N. crassa, did not accu-mulate GpA in the cells under the same conditions as those with a high flavinogenic strain of E. ashbyii.<br> (4) The results obtained indicated that a dinucleotide, GpA, is a com-pound closely related to the biosynthesis of riboflavin.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 23 (5), 403-412, 1977
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詳細情報 詳細情報について
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- CRID
- 1390001206324990848
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- NII論文ID
- 130001372251
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 1913602
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- PubMed
- 146733
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可