Effect of thiamine deficiency, pyrithiamine and oxythiamine on pyruvate metabolism in rat liver and brain in vivo.

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  • MEGHAL S. K.
    Department of Biochemistry, Agricultural Experiment Station, Oklahoma State University Regional Forensic Science Laboratory, State of Maharashtra, Nagpur, India
  • O'NEAL R. M.
    Department of Biochemistry, Agricultural Experiment Station, Oklahoma State University Department of Agriculture, Lincoln University
  • KOEPPE R. E.
    Department of Biochemistry, Agricultural Experiment Station, Oklahoma State University

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  • Effect of thiamine deficiency pyrithiam

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Rats were fed either a thiamine-deficient diet or diets con-taining pyrithiamine or oxythiamine. When symptoms of thiamine deficiency appeared, the animals were injected intraperitoneally with [2-14C] pyruvate six to twelve minutes prior to sacrifice. Free glutamic and aspartic acids were isolated from liver and brain and degraded. The results indicate that, in thiamine-deficient or oxythiamine-treated rats, pyruvate metabolism in liver and brain is similar to that in normal animals. In contrast, pyrithiamine drastically decreases the oxidative decarboxyla-tion of pyruvate by rat liver.

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