Effect of Dietary ^|^gamma;-Aminobutyric Acid on the Nerve Growth Factor and the Choline Acetyltransferase in the Cerebral Cortex and Hippocampus of Ovariectomized Female Rats

DOI Web Site PubMed 参考文献32件
  • TUJIOKA Kazuyo
    Faculty of Early Childhood Care and Education, Ohkagakuen University
  • THANAPREEDAWAT Panicha
    Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, The University of Shizuoka
  • YAMADA Takashi
    Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University
  • YOKOGOSHI Hidehiko
    Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University
  • HORIE Kenji
    Research Department, Pharma Foods International Company Ltd.
  • KIM Mujo
    Research Department, Pharma Foods International Company Ltd.
  • TSUTSUI Kazumi
    Department of Home Economics, Aichi University of Education
  • HAYASE Kazutoshi
    Department of Home Economics, Aichi University of Education

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  • Effect of Dietary γ-Aminobutyric Acid on the Nerve Growth Factor and the Choline Acetyltransferase in the Cerebral Cortex and Hippocampus of Ovariectomized Female Rats

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The brain protein synthesis and the plasma concentration of growth hormone (GH) is sensitive to the dietary γ-aminobutyric acid (GABA) in ovariectomized female rats; however, the role of dietary GABA on biomarkers including nerve growth factor (NGF) and choline acetyltransferase for the function of cholinergic neurons remains unknown in ovariectomized female rats. The purpose of this study was to determine whether the dietary GABA affects the concentration and mRNA level of NGF, and the activity of choline acetyltransferase in the brains of ovariectomized female rats. Experiments were done on two groups of 24-wk-old ovariectomized female rats given 0 or 0.5% GABA added to a 20% casein diet. The concentrations of NGF and activities of choline acetyltransferase in the cerebral cortex and hippocampus, and mRNA level of NGF in the hippocampus increased significantly with the 20% casein+0.5% GABA compared with the 20% casein diet alone. In the hippocampus, the mRNA level of NGF significantly correlated with the NGF concentration (r=0.714, p<0.01). These results suggest that the administration of GABA to ovariectomized female rats is likely to control the mRNA level and concentration of NGF and cause an increase in the activity of choline acetyltransferase in the brains.

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