Effect of wavelength on the photochemical reaction of ergocalciferol (vitamin D2) irradiated by monochromatic ultraviolet light.

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  • 小林 正
    Department of Hygienic Chemistry, Kobe Women's College of Pharmacy, Higashinada-ku
  • 吉本 佐雅子
    Department of Hygienic Chemistry, Kobe Women's College of Pharmacy, Higashinada-ku
  • 康村 満枝
    Department of Hygienic Chemistry, Kobe Women's College of Pharmacy, Higashinada-ku

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  • Effect of Wavelength on the Photochemic

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The effect of wavelength on the photochemical reaction of ergocalciferol (vitamin D2) was investigated. An ergocalciferol solution in ethanol was irradiated by monochromatic UV light of various wave-lengths with a fixed quantum (8.0×108 erg/cm2), trimethylsilylated and then applied to a capillary column GLC as described previously (10) in order to estimate the reaction products. The results showed that UV light in a range of 295-312nm was most effective in the photo-chemical transformation of ergocalciferol into suprasterol2 I and II. The formation of compounds I1, I2, II1 and II2, which had been found as novel reaction products by BAKKER et al. (8), was not exactly confirmed because the former two were thermally isomerized into gyro- and isopyro-D2 via ergocalciferol while the latter two were isomerized into 5, 6-tans-D2 at the temperature for GLC analysis. However, since the peaks caused by gyro- and isopyro-D2 were observed to be rather large in the gas chromato-grams of long-term irradiated solutions, although no information on the existence of ergocalciferol was obtained from the UV spectra and TLC of the solutions, significant amounts of the compounds I1 and I2 might be formed by irradiation of ergocalciferol. On the other hand, the peak due to 5, 6-taans-D2 was observed to be very small in the gas chromato-grams of irradiated solutions with different wavelengths although no information on the existence of 5, 6-taans-D2 was also obtained from the results of TLC. Therefore, the photochemical transformation of ergo-calciferol into compounds II1 and II2 might occur to only a small extent regardless of irradiated wavelengths.

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