Effects of Sugar-Sweetened Beverage Intake on Development of Type 2 Diabetes Mellitus in Subjects with Impaired Glucose Tolerance : the Mihama Diabetes Prevention Study

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  • TESHIMA Nobuko
    Division of Dietary Service, Mie University Hospital
  • SHIMO Miho
    Department of Health and Welfare, Mihama Town
  • MIYAZAWA Kae
    Department of Health and Welfare, Mihama Town
  • KONEGAWA Sachi
    Department of Health and Welfare, Mihama Town
  • MATSUMOTO Aki
    Department of Clinical Diabetes and Endocrinology, Mie University Hospital
  • ONISHI Yuki
    Department of Clinical Diabetes and Endocrinology, Mie University Hospital
  • SASAKI Ryoma
    Department of Clinical Diabetes and Endocrinology, Mie University Hospital
  • SUZUKI Toshinari
    Department of Clinical Diabetes and Endocrinology, Mie University Hospital
  • YANO Yutaka
    Department of Clinical Diabetes and Endocrinology, Mie University Hospital
  • MATSUMOTO Kazutaka
    Department of Clinical Diabetes and Endocrinology, Mie University Hospital
  • YAMADA Tomomi
    Department of Clinical Epidemiology and Biostatistics, Graduate School of Medicine, Osaka University
  • GABAZZA Esteban Cesar
    Department of Immunology, Division of Molecular and Experimental Medicine, Mie University Graduate School of Medicine
  • TAKEI Yoshiyuki
    Department of Gastroenterology and Hepatology, Mie University Hospital
  • SUMIDA Yasuhiro
    Yokkaichi Hazu Medical Center

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タイトル別名
  • Effects of Sugar-Sweetened Beverage Intake on the Development of Type 2 Diabetes Mellitus in Subjects with Impaired Glucose Tolerance: the Mihama Diabetes Prevention Study

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In Japan, the incidence of type 2 diabetes mellitus (T2DM) is increasing for several reasons, including increased consumption of sugar-sweetened beverages (SSBs). However, whether SSBs cause T2DM by excess of energy production resulting in obesity remains unclear. Therefore, the present study was designed to evaluate the effects of SSB intake on the development of T2DM in subjects with impaired glucose tolerance (IGT). Ninety-three subjects (30 males and 63 females) with IGT aged 40-69 y and residing in the Mihama district (southern Mie Prefecture, Japan) were included in the study. The mean observational period was 3.6 y. All subjects underwent the 75-g oral glucose tolerance test (OGTT) and completed a lifestyle questionnaire survey related to SSB intake. OGTT results and SSB intake were evaluated before and after the observational period. In addition, the correlation between SSB intake and development of T2DM was investigated. Of the 93 subjects, 20 (21.5%) developed T2DM (T2DM group) and demonstrated a significantly high SSB intake compared with the group that did not develop the disease (non-T2DM group). The odds ratio for the incidence of T2DM based on SSB intake was 3.26 (95% confidence interval, 1.17-9.06). The body mass index (BMI; kg/m2) and the homeostasis model assessment for insulin resistance (HOMA-R) values was significantly higher in the T2DM group than in the non-T2DM group, while the insulinogenic indices were significantly lower in the former than in the latter group. The sum of insulin secretion levels during OGTT was not significantly different between groups. SSB intake correlated with the predisposition for developing T2DM, possibly by influencing body weight, insulin resistance, and the ability of the pancreatic beta cells to effectively compensate for the insulin resistance.

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