Studies on the Mechanism of Antihypertensive Action by Nicotianamine
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- HAYASHI Atsumi
- Department of Food and Nutrition, Tokyo Kasei University
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- KIMOTO Koichi
- Department of Food and Nutrition, Tokyo Kasei University
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Nicotianamine (NA), which is obtained from vegetables, lowers blood pressure through the renin-angiotensin system, and we clarified that NA preferentially inhibits the activity of angiotensin I-converting enzyme (ACE)—a zinc-containing enzyme. In this study, we elucidated the mechanism of antihypertensive action of NA through the Magnus method by using rat aortic blood vessels. Angiotensin I-induced contractions were inhibited by NA in a concentration-dependant manner. Because NA did not inhibit angiotensin II-induced contractions, it was believed that NA inhibited ACE activity in vascular smooth muscles. NA did not affect KCl-induced contractions, but it affected norepinephrine-induced contractions to a small extent. NA exerted similar effects on endothelium-denuded and endothelium-intact blood vessels. Therefore, the antihypertensive action of NA did not play a role in the opening of voltage-dependent calcium channels, but this effect influenced vasoconstriction by the activation of α-adrenergic receptors. These results suggest that after absorption from the intestinal tract, NA may exert antihypertensive effects via 2 mechanisms: direct inhibition of ACE in vascular smooth muscle and activation of α-adrenergic receptors.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 56 (4), 242-246, 2010
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詳細情報 詳細情報について
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- CRID
- 1390001206325400832
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- NII論文ID
- 10026569926
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC3cXhtFensrvN
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 10793730
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- PubMed
- 20924146
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- 本文言語コード
- en
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- データソース種別
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- IRDB
- NDL
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- PubMed
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