High Incidence of Lipid Deposition in the Liver of Rats Fed a Diet Supplemented with Branched-Chain Amino Acids under Vitamin B<sub>6</sub> Deficiency
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- KAIMOTO Tae
- Department of Living Science, Shikoku University
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- SHIBUYA Mayumi
- Department of Living Science, Shikoku University
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- NISHIKAWA Kazutaka
- Faculty of Health and Living Sciences, Graduate School of Education, Naruto University of Education
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- MAEDA Hideo
- Faculty of Health and Living Sciences, Graduate School of Education, Naruto University of Education
Bibliographic Information
- Other Title
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- High Incidence of Lipid Deposition in the Liver of Rats Fed a Diet Supplemented with Branched-Chain Amino Acids under Vitamin B₆ Deficiency
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Abstract
Male Wistar rats were fed four diets composed of purified 20% vitamin-free casein diet with (+) or without (−) vitamin B6 (7.0 mg of pyridoxine HCl/kg of diet) and with (+) or without (−) branched-chain amino acids (BCAAs) of valine, leucine, and isoleucine (4.75%): B6(+)BCAA(−); B6(+)BCAA(+); B6(−)BCAA(−); and B6(−)BCAA(+) for 21 d. Among rats fed the B6(−)BCAA(+) diet, about a half showed lipid deposition in the liver. On the other hand, serum triacylglycerol levels in the B6(−)BCAA(+) group tended to be decreased. Hepatic triacylglycerol and cholesterol levels tended to increase in the B6(−)BCAA(+) group compared with the other three groups. Serum apolipoprotein B and apolipoprotein E (apo E) levels in the B6(−)BCAA(+) group were the lowest among the three groups. In contrast, hepatic apo E levels in the B6(−)BCAA(+) group were the highest among the three groups. High-performance liquid chromatography of pooled serum of rats with lipid deposits revealed that triacylglycerol and cholesterol levels in very low-density lipoprotein (VLDL) were decreased compared with other diet groups. These results strongly suggest that one of the mechanisms of lipid deposition in rats fed a B6(−)BCAA(+) diet is due to impaired secretion of VLDL.
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 59 (1), 73-78, 2013
Center for Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1390001206325441920
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- NII Article ID
- 130003368152
- 40019602860
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- NII Book ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC3sXktlels7k%3D
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 024316103
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- PubMed
- 23535543
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed
