HDL3 Exerts a More Powerful Antiperoxidative and Protective Effect against Peroxidative Modification of LDL than HDL2 Does.

DOI Web Site 被引用文献2件 参考文献30件
  • SAKUMA Nagahiko
    Third Department of Interrial Medicine, Second Department of Biochemistry, Nagoya City University Medical School
  • YOSHIKAWA Masae
    Third Department of Interrial Medicine, Second Department of Biochemistry, Nagoya City University Medical School
  • HIBINO Takeshi
    Third Department of Interrial Medicine, Second Department of Biochemistry, Nagoya City University Medical School
  • OHTE Nobuyuki
    Third Department of Interrial Medicine, Second Department of Biochemistry, Nagoya City University Medical School
  • KAMIYA Takeshi
    Third Department of Interrial Medicine, Second Department of Biochemistry, Nagoya City University Medical School
  • KUNIMATSU Mitoshi
    Third Department of Interrial Medicine, Second Department of Biochemistry, Nagoya City University Medical School
  • KIMURA Genjiro
    Third Department of Interrial Medicine, Second Department of Biochemistry, Nagoya City University Medical School
  • INOUE Makoto
    Department of Pharmacognosy, Nagoya City University Faculty of Pharmaceutical Sciences

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The objective of the present study was to establish that HDL3 has a greater antiperoxidative effect on the peroxidative modification of LDL than HDL2 has. The protective influence of HDL subfractions on this form of LDL modification was examined in samples by measuring the concentration of thiobarbituric acid-reactive substance (TBARS), as well as the electrophoresic mobility of LDL. LDL was incubated for 96 hours in phosphate-buffered saline (PBS) alone, without the addition of transition-metal ions or in the presence of PPS and HDL2 or HDL3. All samples were subjected to agarose gel electrophoresis. Both HDL2 and HDL3 significantly inhibited peroxidative modification of LDL, as assessed by electrophoretic mobility, but this effect was much more pronounced with HDL3. HDL3 may play a more important role than HDL2 in the prevention of atherosclerosis in vivo by more effectively inhibiting LDL peroxidation.

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