Effect of histidine-free and -excess diets on anserine and carnosine contents in rat gastrocnemius muscle.

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  • 玉木 七八
    Laboratory of Nutritional Chemistry, Faculty of Nutrition, Kobe-Gakuin University
  • 常森 ふさ子
    Laboratory of Nutritional Chemistry, Faculty of Nutrition, Kobe-Gakuin University
  • 若林 道子
    Laboratory of Nutritional Chemistry, Faculty of Nutrition, Kobe-Gakuin University
  • 浜 堯夫
    Laboratory of Nutritional Chemistry, Faculty of Nutrition, Kobe-Gakuin University

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  • Effect of Histidine Free and Excess Die

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Anserine and carnosine contents were determined in muscle of rats subjected to histidine depletion or excessive supplement. The contents of anserine and carnosine were reduced in the gastro-cnemius muscle of rats fed a histidine-free diet. The diet showed especial-ly a remarkable decrease of carnosine content. After rehabilitation for one week, the muscle anserine and carnosine contents in histidine-deficient rat returned to the normal level.<br>The body and gastrocnemius muscle weights were decreased in rats fed a histidine-excess diet. However, anserine and carnosine content in muscle of rats fed a histidine-excess diet were twice of that of control rats.<br>Urinary excretion of Nπ-methylhistidine and Nτ-methylhistidine was in-creased in rats fed a histidine-excess diet.

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