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- SATO Ryuichiro
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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Abstract
Cholesterol is a major component of membrane lipids. Thus, adjusting the membrane cholesterol composition is essential for maintaining cellular homeostasis. Cholesterol biosynthesis and uptake by LDL receptors are tightly regulated at the transcriptional level through negative feedback control, which is mediated by sterol regulatory element-binding proteins (SREBPs). In particular, SREBP-2 is activated in a cholesterol-dependent manner and, thus, is significantly involved in regulating the expression of those genes associated with cholesterol metabolism. Cholesterol metabolites such as oxysterols are involved in regulating sterol metabolism by binding to the nuclear receptor, liver X receptor (LXR). Cholesterol catabolites, i.e., bile acids, are agonists for another nuclear receptor, farnesoid X receptor (FXR), and a bile acid receptor, TGR5. Activated FXR regulates bile acid metabolism and TGR5 improves glucose metabolism through the actions of glucagon-like peptide-1 (GLP-1).
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 61 (Supplement), S151-S153, 2015
Center for Academic Publications Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001206325843072
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- NII Article ID
- 130005109889
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- NII Book ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 026364872
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- PubMed
- 26598835
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed