Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats
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- HIRAO Akira
- Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- YAMASAKI Masao
- Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- CHUJO Hitoi
- Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- KOYANAGI Nami
- Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- KANOUCHI Hiroaki
- Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- YASUDA Shin
- Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- MATSUO Aya
- Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- NISHIDA Eri
- Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- RIKIMARU Tatsuya
- Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
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- TSUJITA Eiji
- Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
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- SHIMADA Mitsuo
- Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
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- MAEHARA Yoshihiko
- Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
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- TACHIBANA Hirofumi
- Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
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- YAMADA Koji
- Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
この論文をさがす
説明
We examined the effect of dietary conjugated linoleic acid (CLA) on liver regeneration after a partial hepatectomy (PH) in Sprague-Dawley rats. PH Was performed on rats fed a 0 or 1 wt.% CLA diet for 3 wk. Average liver weight in the CLA fed rat popula-tion was heavier than the control rat population at the time of PH and 1-d after PH. Con-versely, CLA fed raduced liver weight was significantly lower than control rats at 7-d after PH. This suggests that dietary CLA reduced liver weight gain after PH. Dietary CLA did not affect serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) activities. How-ever, CLA significantly reduced serum albumin levels at 1-d but not at 7-d after PH. 5-Promo- and 5-iododeoxyuridine incorporation into hepatocytes 1-d post PH was lower in the CLA group. In conclusion, the data suggests that dietary CLA inhibits DNA synthesis after PH, which results in hepatocyte proliferation inhibition.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 50 (1), 9-12, 2004
一般財団法人 学会誌刊行センター
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詳細情報 詳細情報について
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- CRID
- 1390001206325859072
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- NII論文ID
- 110002703957
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD2cXitV2nsbw%3D
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- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
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- NDL書誌ID
- 6866403
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- PubMed
- 15228211
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可