Sea Cucumber Saponin Echinoside A (EA) on Hepatic Fatty Acid β-Oxidation and Suppresses Fatty Acid Biosynthesis Coupling in a Diurnal Pattern

DOI Web Site Web Site PubMed 参考文献35件
  • WEN Min
    College of Food Science and Engineering, Ocean University of China
  • FU Xueyuan
    College of Food Science and Engineering, Ocean University of China
  • HAN Xiuqing
    College of Food Science and Engineering, Ocean University of China
  • HU Xiaoqian
    College of Food Science and Technology, ShangHai Ocean University
  • DONG Ping
    College of Food Science and Engineering, Ocean University of China
  • XU Jie
    College of Food Science and Engineering, Ocean University of China
  • XUE Yong
    College of Food Science and Engineering, Ocean University of China
  • WANG Jingfeng
    College of Food Science and Engineering, Ocean University of China
  • XUE Changhu
    College of Food Science and Engineering, Ocean University of China
  • WANG Yuming
    College of Food Science and Engineering, Ocean University of China

書誌事項

タイトル別名
  • Sea Cucumber Saponin Echinoside A (EA) Stimulates Hepatic Fatty Acid β-Oxidation and Suppresses Fatty Acid Biosynthesis Coupling in a Diurnal Pattern
  • Sea Cucumber Saponin Echinoside A (EA) Stimulates Hepatic Fatty Acid β-Oxidation and Suppresses Fatty Acid Biosynthesis Coupling in a Diurnal Pattern

この論文をさがす

説明

Circadian rhythms control aspects of physiological events, including lipid metabolism, showing rhythmic fluctuation over 24 h. Therefore, it is not sufficient to evaluate thoroughly how dietary components regulate lipid metabolism with a single time-point assay. In the present study, a time-course study was performed to analyze the effect of sea cucumber saponin echinoside A (EA) on lipid metabolism over 24 h. Results showed that EA lowered the levels of TC and TG in both serum and liver at most time-points during the 24 h. Activities of hepatic lipogenic enzymes and lipolytic enzymes were inhibited and elevated respectively by EA to varied degrees at different time-points. Meanwhile, parallel variation trends of gene expression involved in fatty acid synthesis and β-oxidation were observed accordingly. The interaction between EA and lipid metabolism showed a time-dependent effect. Overall, EA impaired fatty acid synthesis and enhanced mitochondrial fatty acid β-oxidation in ad libitum feeding over 24 h.

収録刊行物

参考文献 (35)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ