.ALPHA.-Tocopheryl Succinate Activates Protein Kinase C in Cellular and Cell-Free Systems

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  • KOGURE Kentaro
    Faculty of Pharmaceutical Sciences, The University of Tokushima
  • HAMA Susumu
    Faculty of Pharmaceutical Sciences, The University of Tokushima
  • GOTO Satoru
    Faculty of Pharmaceutical Sciences, The University of Tokushima
  • MUNAKATA Tatsuo
    Department of Industrial Chemistry, Faculty of Engineering, Tohwa University
  • TOKUMURA Akira
    Faculty of Pharmaceutical Sciences, The University of Tokushima
  • FUKUZAWA Kenji
    Faculty of Pharmaceutical Sciences, The University of Tokushima

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  • α-Tocopheryl Succinate Activates Protein Kinase C in Cellular and Cell-Free Systems
  • アルファ Tocopheryl Succinate Activates Protein Kinase C in Cellular and Cell Free Systems

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The effect of a-tocopheryl succinate (TS) on protein kinase C (PKC) activity was examined. TS increased the auto-phosphorylation of PKC in vascular smooth muscle cells. Furthermore TS activated isolated PKC-like phorbol 12-myristate 13-acetate (PMA), although it was required at a significantly higher concentration than PMA for PKC activation. Molecular superimposition of the TS on PMA by computation suggested that TS took an active binding conformation to the PKC-like PMA, but that the conformational population was about 1/1 000. Consequently, we conclude that TS interacts directly with PKC, and activates it by taking an active conformation like PMA.

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