Comparative Effect of Dietary Olive, Safflower, and Linseed Oils on Spontaneous Liver Tumorigenesis in C3H/He Mice.

DOI Web Site PubMed 参考文献31件
  • THUY Nguyen Thi Thu
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University The United Graduate School of Agricultural Science, Gifu University
  • HE Puming
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • TAKEUCHI Hisanao
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University The United Graduate School of Agricultural Science, Gifu University

この論文をさがす

抄録

In male C3H/He mice, which frequently develop spontaneous liver tumorige-nesis, 5 wk of age and weighing about 20 g, the comparative effects on liver tumor inci-dence from the feeding of olive oil (OLI), safflower oil (SAP), and linseed oil (US) diets for 50 wk, the concentrations of total cholesterol (T-CHOL), triacylglycerol (TG), lipid peroxides in the plasma and liver, and the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the plasma were examined. The changes in body weight and liver weight were not different among dietary groups. The number of mice bearing liver ade-noma was greater in the SAP group than in the OLI and US groups. Liver carcinoma was observed in the SAP group, but not in the OLI and US groups. The concentrations of T-CHOL in the plasma and liver were higher in the OLI group than in the other groups. TG levels in the plasma and liver were highest in the OLI group and followed in order by the SAP and US groups. The concentration of plasma lipid peroxide was higher in the US group than in the other groups. Liver lipid peroxide content was extremely high in the US group, medium in the SAP group, and low in the OUT group. The activity of AST was highest in the OUT group and followed in order by the SAP and LIS groups. ALT activity was higher in the OUT group than in the other groups. A positive relationship between spontaneous liver tumorigenesis and the concentrations of T-CHOL, TG, and lipid peroxide or AST and ALT activities was hardly observed. These results suggested that spontaneous tumorigenesis in the liver of male C3H/He mice bred for 50 wk was suppressed by being supplied with OUT and LIS, compared with SAP, which had no direct relation to the concen-trations of T-CHOL, TG, and lipid peroxide in the plasma and liver and the activities of plasma AST and ALT.

収録刊行物

参考文献 (31)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ