Different Recovery Responses from Dietary Zinc-Deficiency in the Distribution of Rat Granulocytes

DOI Web Site 被引用文献1件 参考文献40件
  • SAKAKIBARA Yuko
    Laboratory of Physiological Sciences, Graduate School of Human Sciences, Waseda University
  • SATO Shogo
    Laboratory of Physiological Sciences, Graduate School of Human Sciences, Waseda University Japan Society for the Promotion of Science
  • KAWASHIMA Yu
    School of Medicine, University of Yamanashi
  • SOMEYA Yui
    Laboratory of Physiological Sciences, Graduate School of Human Sciences, Waseda University
  • SHIRATO Ken
    Institute of Scientific and Industrial Research, Osaka University
  • TACHIYASHIKI Kaoru
    Department of Natural and Living Sciences, Graduate School of Education, Joetsu University of Education
  • IMAIZUMI Kazuhiko
    Laboratory of Physiological Sciences, Graduate School of Human Sciences, Waseda University

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The purpose of this study was to elucidate the effects of the recovery from dietary zinc-deficiency on the number of total white blood cells (WBCs), neutrophils, eosinophils and basophils, and plasma zinc and corticosterone concentrations in weanling male Sprague Dawley rats. Rats (n=34) of the zinc-deficient diet (0.6 mg zinc/kg diet) and control diet (35.2 mg zinc/kg diet) groups were fed for 4 wk, and then rats of both groups were fed with the control diet for 3 wk. Zinc-deficiency increased duration-dependently and clearly the number of total WBCs, neutrophils and eosinophils, and the increased numbers of these cells recovered to the control levels in week 2 of the recovery. On the other hand, the number of basophils increased by the zinc-deficiency recovered to the control levels in week 1 of the recovery. Zinc-deficiency significantly decreased plasma zinc concentrations by 85%, and markedly increased plasma corticosterone concentrations by 317%, as compared with the control group. In the recovery period, plasma zinc and corticosterone concentrations recovered to the control levels in week 2 of the recovery. These results suggest that zinc-deficiency and its recovery responses in the number of granulocytes and total WBCs are reversible, and their recovery rates depend on the subsets of granulocytes in rats.

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