Dietary Medium-Chain Triglycerides Attenuate Hepatic Lipid Deposition in Growing Rats with Protein Malnutrition
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- KUWAHATA Masashi
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- KUBOTA Hiroyo
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- AMANO Saki
- Department of Molecular Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
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- YOKOYAMA Meiko
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- SHIMAMURA Yasuhiro
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- ITO Shunsuke
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- OGAWA Aki
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- KOBAYASHI Yukiko
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- MIYAMOTO Ken-ichi
- Department of Molecular Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
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- KIDO Yasuhiro
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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説明
The objective of this study was to investigate the effects of dietary medium-chain triglycerides (MCT) on hepatic lipid accumulation in growing rats with protein malnutrition. Weaning rats were fed either a low-protein diet (3%, LP) or control protein diet (20%, CP), in combination with or without MCT. The four groups were as follows: CP-MCT, CP+MCT, LP−MCT, and LP+MCT. Rats in the CP−MCT, CP+MCT and LP+MCT groups were pair-fed their respective diets based on the amount of diet consumed by the LP−MCT group. Rats were fed each experimental diet for 30 d. Four weeks later, the respiratory quotient was higher in the LP−MCT group than those in the other groups during the fasting period. Hepatic triglyceride content increased in the LP groups compared with the CP groups. Hepatic triglyceride content in the LP+MCT group, however, was significantly decreased compared with that in the LP−MCT group. Levels of carnitine palmitoyltransferase (CPT) 1a mRNA and CPT2 mRNA were significantly decreased in the livers of the LP−MCT group, as compared with corresponding mRNA levels of the other groups. These results suggest that ingestion of a low-protein diet caused fatty liver in growing rats. However, when rats were fed the low-protein diet with MCT, hepatic triglyceride deposition was attenuated, and mRNA levels encoding CPT1a and CPT2 were preserved at the levels of rats fed control protein diets.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 57 (2), 138-143, 2011
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詳細情報 詳細情報について
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- CRID
- 1390001206326715648
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- NII論文ID
- 10030028800
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC3MXlvVegu7g%3D
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 11054010
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可