Regulation of luteal function by post-ovulatory luteinizing hormone secretion in 4-day and 5-day cycling rats.

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  • HASHIMOTO Inoru
    Laboratories of Veterinary Physiology and Anatomy, Kitasato University School of Veterinary Medicine and Animal Sciences
  • AIZAWA Katsuya
    Laboratories of Veterinary Physiology and Anatomy, Kitasato University School of Veterinary Medicine and Animal Sciences
  • SEYA Yuichi
    Laboratories of Veterinary Physiology and Anatomy, Kitasato University School of Veterinary Medicine and Animal Sciences
  • KOMODA Yasushi
    Laboratories of Veterinary Physiology and Anatomy, Kitasato University School of Veterinary Medicine and Animal Sciences
  • HIGASHINO Kohji
    Laboratories of Veterinary Physiology and Anatomy, Kitasato University School of Veterinary Medicine and Animal Sciences
  • MUTOH Ken-ichiro
    Laboratories of Veterinary Physiology and Anatomy, Kitasato University School of Veterinary Medicine and Animal Sciences
  • KAWAMINAMI Mitsumori
    Laboratories of Veterinary Physiology and Anatomy, Kitasato University School of Veterinary Medicine and Animal Sciences

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Other Title
  • 排卵後の黄体形成ホルモン(LH)分泌によるラット発情周期黄体機能の調節
  • 排卵後の黄体形成ホルモン(LH)分泌によるラット発情周期黄体機能の調節〔英文〕
  • ハイランゴ ノ オウタイケイセイ ホルモン LH ブンピ ニ ヨル ラット ハ

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Abstract

Concerning effects of post-ovulatory anti-LH serum (aLH) administration on luteal progesterone (P) secretion and reactivity to prolactin (PRL), comparisons were made between 4-and 5-day cycles. Plasma P declined by 6:00 hr on diestrus (D) in control 4-day cycling rats and by 18:00 hr on day D in control 5-day cycling rats. Daily injections of aLH from 8:00 hr on estrus (E) in 4-day cycles did not alter P secretion. However, aLH injections from 8:00 hr on metestrus (M) prolonged P secretion up to 18:00 hr on day D, while aLH injections from 19:00 hr on day M failed to prolong P secretion. In 5-day cycles, aLH injections from 8:00 hr on day E or 19:00 hr on day M prolonged P secretion. Control 4-day cycling rats responded to PRL injections from 8:00 hr on day M with elevated P secretion and persistent leukocytic vaginal smears for 9-10 days, but they failed to respond to PRL injections from 19:00 hr on day D. Control 5-day cycling rats also failed to respond to PRL injections from 19:00 hr on day D. Injections of aLH from 8:00 hr on day M in 4-day cycles preserved the full luteal re-activity at 19:00 hr on day D. The aLH injections from 19:00 hr on day M maintained the full luteal reactivity at 19:00 hr on day D in 5-day cycles, but not in 4-day cycles. At 18:00 hr on day D, changes in the fine structure of the lutein cells from control and aLH-treated 4-day cycling rats were correlated to those in plasma P levels. These results indicate (1) tonic LH levels on day E of 4-day cycles "enhance" luteal P secretion, (2) tonic levels of LH secreted on day M suppress luteal function, which has a structural basis, (3) the suppressive effect is imposed at least 11 hr later in 5-day cycles than in 4-day cycles.

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