A New Method for Measuring the Oxygen Diffusion Constant and Oxygen Consumption Rate of Arteriolar Walls

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  • Sasaki Nobuhiko
    Graduate School of Science and Technology, Keio University, Tokyo, Japan
  • Horinouchi Hirohisa
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
  • Ushiyama Akira
    Department of Environmental Health, National Institute of Public Health, Saitama, Japan
  • Minamitani Haruyuki
    Graduate School of Science and Technology, Keio University, Tokyo, Japan

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Oxygen transport is believed to primarily occur via capillaries and depends on the oxygen tension gradient between the vessels and tissues. As blood flows along branching arterioles, the O2saturation drops, indicating either consumption or diffusion. The blood flow rate, the O2concentration gradient, and Krogh’s O2diffusion constant (K) of the vessel wall are parameters affecting O2delivery. We devised a method for evaluatingKof arteriolar wallin vivousing phosphorescence quenching microscopy to measure the partial pressure of oxygen in two areas almost simultaneously. TheKvalue of arteriolar wall (inner diameter, 63.5 ± 11.9 μm; wall thickness, 18.0 ± 1.2 μm) was found to be 6.0 ± 1.2 × 10−11(cm2/s)(ml O2·cm−3tissue·mmHg−1). The arteriolar wall O2consumption rate (M) was 1.5 ± 0.1 (ml O2·100 cm−3tissue·min−1), as calculated using Krogh’s diffusion equation. These results suggest that the arteriolar wall consumes a considerable proportion of the O2that diffuses through it.

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