牛直腸内への臭化プリフィニウム投与による直腸の蠕動運動抑制効果

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タイトル別名
  • Inhibitory Effect of Prifinium Bromide after Intrarectal Adminis-tration on the Rectal Peristalic Movement in Bovine
  • ウシ チョクチョウナイ エ ノ シュウカ プリフィニウム トウヨ ニ ヨル チ

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説明

The inhibitory effect of prifinium bromide on the rectal peristalic movement, after intrarectal administration (200 mg) or intravenous administration (75 mg) was studied in two heifers and two cows or two cows, respectively in examination 1. After intrarectal or intravenous administration, the inhibition of rectal peristalic movement was rapidly initiated within 20 sec to 44 sec or 5 sec to 10 sec and continued for 10 to 50 minutes or 43 to 50 minutes, respectively.<BR>The contraction of rectum was recorded using devised monitoring apparatus. The contraction of rectum occurred 2 to 8 times (18-40 mmHg/contraction), intermittently, before recovery to normal peristalic movement.<BR>In examination 2, 25 and 17 donors or 77 and 26 recipients were treated intrarectally with 200 mg and intravenously with 75 mg of prifinium bromide respectively. Among 19 of 25 (76%) and 15 of 17 (88%) donors, 68 of 77 (88%) and 25 of 26 (96%) recipients the treatment showed good efficacy for inhibition of the rectal peristalic movement for intrarectal and intravenous administration respectively. However there were some individual variations.

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