反芻動物の卵巣における黄体形成ホルモンレセプターの発現調節ならびに卵胞嚢腫の発生機構に関する研究
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- KAWATE Noritoshi
- Laboratory of Theriogenology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University
書誌事項
- タイトル別名
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- Studies on the Regulation of Expression of Luteinizing Hormone Receptor in the Ovary and the Mechanism of Follicular Cyst Formation in Ruminants
- JSAR Outstanding Research Award: Studies on the Regulation of Expression of Luteinizing Hormone Receptor in the Ovary and the Mechanism of Follicular Cyst Formation in Ruminants
この論文をさがす
抄録
In the series of studies, changes of expression and regulation of luteinizing hormone (LH) receptor in the ovary of domestic ruminants were examined. Furthermore, mechanisms of formation of follicular cysts in domestic ruminants, caused by stress and so on, were endocrinologically elucidated. Results of the studies provide the following conclusions. (1) The quantity of LH receptor in the bovine antral follicles increases rapidly in the latter stage of its development. (2) The quantity of LH receptor and its mRNA in the bovine and caprine corpus luteum increase during their developments. The increase of the receptor in the caprine luteal development is regulated by LH through the receptor mRNA level. (3) At least, three splice variants of LH receptor mRNA exist in the bovine luteal tissue and the variant receptors are expressed at different cellular sites according to its structure. (4) Intracellular consecutive cysteine residues of LH receptor are palmitoylated and thereby inhibit internalization of the receptor. (5) As a mechanism of the bovine follicular cyst caused by stress, it is suggested that increased secretions of progesterone and cortisol from the adrenal gland exert inhibitory effects on the hypothalamus and follicle, respectively, and subsequently LH and FSH surges are blocked, then finally ovulation is suppressed and the follicle becomes cystic.<br>
収録刊行物
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 50 (1), 1-8, 2004
公益社団法人 日本繁殖生物学会
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詳細情報 詳細情報について
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- CRID
- 1390001206337547904
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- NII論文ID
- 130000054834
- 10026620648
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- NII書誌ID
- AA10936678
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- DOI
- 10.1262/jrd.50.1
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- ISSN
- 13484400
- 09168818
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- NDL書誌ID
- 6867306
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- PubMed
- 15007196
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可