Estrus synchronization in microminipig using estradiol dipropionate and prostaglandin F<sub>2α</sub>
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- NOGUCHI Michiko
- Department of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan
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- IKEDO Tomonobu
- Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan
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- KAWAGUCHI Hiroaki
- Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
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- TANIMOTO Akihide
- Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
Bibliographic Information
- Other Title
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- Estrus synchronization in microminipig using estradiol dipropionate and prostaglandin F₂α
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Abstract
<p> The induction of pseudopregnancy by the exogenous administration of estradiol dipropionate (EDP) was investigated in cyclic Microminipigs (MMpigs) and the effects of exogenous administration of prostaglandin (PG) F2α on estrus exhibition were assessed in pseudopregnant MMpigs. In experiment 1, ovariectomized MMpigs were given a single intramuscular injection of 0.5, 1.5, or 2.5 mg of EDP. The estradiol-17β level at each of these doses was significantly higher 1 to 3 days after EDP administration than on the day of the injection. In experiment 2, animals were given 1.5 mg of EDP once at 9 to 12 days after the end of estrus (D0) and then no (1.5 mg × 1 group), one (D0 and D4; 1.5 mg × 2 group), or two (D0, D4 and D7; 1.5 mg × 3 group) additional treatments. The pseudopregnancy rate was significantly higher in the 1.5 mg × 3 than in the 1.5 mg × 1 group. In experiment 3, PGF2α was administered twice between 26 and 28 days after EDP treatment to five pseudopregnant gilts with a 24-h interval between the two injections. Estrus after PGF2α treatment and LH surge were observed in 100% and 80% pseudopregnant MMpigs, respectively. The interval from the day of the first PGF2α treatment to the onset of estrus was 6.5 ± 0.2 days. These results indicate that multiple EDP treatments are required for induction of pseudopregnancy in MMpigs and estrus exhibition can be controlled in MMpigs by treatment with EDP and PGF2α.</p>
Journal
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 62 (4), 373-378, 2016
The Society for Reproduction and Development
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Details 詳細情報について
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- CRID
- 1390001206337777152
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- NII Article ID
- 130005406792
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- NII Book ID
- AA10936678
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- ISSN
- 13484400
- 09168818
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- NDL BIB ID
- 027571418
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- PubMed
- 27151362
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed