Stress-induced Biomarkers in Liver with Non-alcohol Fatty Liver Diseases and Non-alcohol Steatohepatitis

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  • Ono Hiromi
    Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University
  • Tanaka Akira
    Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University Nutrition Clinic, Kagawa Nutrition University
  • Nakazato Kyoumi
    Gunma University Graduate School of Health Sciences
  • Hasegawa Yutaka
    Educational Center for Clinical Pharmacy, Kobe Pharmaceutical University
  • Kim Ke Ih
    Department of Gastroenterology, Kobe Asahi Hospital
  • Kim Soo Ryang
    Department of Gastroenterology, Kobe Asahi Hospital
  • Nakajima Katsuyuki
    Nutrition Clinic, Kagawa Nutrition University Gunma University Graduate School of Health Sciences
  • Nagamine Takeaki
    Gunma University Graduate School of Health Sciences

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Background & Aims : A comparative study between plasma diagnostic markers and oxidative stress-induced biomarkers localized differently in the liver has not been reported in non-alcohol fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH). Methods : Pathological observations by Hematoxylin and Eosin (HE) staining and immunostaining by specific antibodies against metallothionein (MT)-1/2 and -3, heme oxygenase -1(HO-1), adiponectin using biopsy samples and plasma diagnostic makers were determined in 37 cases. Results : The MT-1/2, HO-1 and adiponectin levels were all significantly reduced in the liver with NASH compared with NAFLD and control. MT-1/2 was most strongly stained in hepatocytes in the normal and NAFLD liver, while it was significantly reduced in NASH. Adiponectin was stained significantly less at blood vessels in NASH compared with NAFLD and controls. HO-1 was also stained significantly less in the Kupffer cells in NASH compared with NAFLD and controls. MT-3 was stained similarly among the three groups at blood vessel cells. Those biomarkers trended negatively with plasma liver injury biomarkers. Conclusions : The significantly reduced expression of oxidative stress-induced biomarkers in NASH may be associated with the degree of pathological damage. In particular, MT-1/2 appears to exert an important effect in hepatocytes against stress-induced damage in NASH.

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