Local Hemostatic Effect of Electrolyzed Neutral Water in Cutting Wound Surface of Mice Tail

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  • マウス尾部切断創における電解中性水の局所止血効果

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Abstract

Electrolyzed acid water has been used for sterilizing and washing in dental practice because of strong bactericidal effects. Recently, electrolyzed neutral water (NW), which is called second-generation soft electrolyzed water, was developed. NW has excellent bactericidal effects, less corrosive effect on materials than electrolyzed acid water. Experientially, NW appears to be effective in stopping small hemorrhage. In this study, we examined the hemostatic effect of NW in animal testing. The end part of the mice tail was cut off under general anesthesia and the remaining surface of amputation was immersed in 2ml NW for 30 seconds. After the immersion, a piece of filter paper was put on the incised surface to absorb the blood and time to stop bleeding was measured. The same measurements were carried out with three commercial dental local hemostatics for dental use : Bosmin^[○!R] solution, Liquid thrombin, TDZ. NW significantly shortened bleeding time compared with non-treatment. The effect of NW was at the same level as that of Bosmin^[○!R] solution and Liquid thrombin. For further consideration, samples and mice blood were blended and observed the change with the naked eye. Hemolysis was found in the case of NW, and blood clot appeared in TDZ. Hemostatic mechanism of NW seems to be different from that of TDZ. These results suggest that NW shows hemostatic effect clinically and is useful for rinsing or gargling in such cases with small blood oozing as alveolar pyorrhoea and wound after extraction of teeth.

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