口腔粘膜組織内における IgA の局在及びその起源について

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タイトル別名
  • Localization and Origin of IgA in Oral Mucosa
  • コウコウ ネンマク ソシキナイ ニ オケル IgA ノ キョクザイ オヨビ ソ

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The distributions of IgA, IgG and albumin in the oral mucosa were studied by the immunofluorescent technique. The cause of the localization of IgA in tissue was also considered. The results obtained were as follows. 1. Most of IgA resided only in the keratinized layer of the oral mucosa. On the other hand IgG were localized in the submucosal tissue. Albumin were distributed in both tissues. 2. After a short term (2 hr) of the washing by various solutions, IgA remained in the keratinized layer in all tested cases as that were. The fact suggests that IgA did not preferentially bind to the tissue by ionic forces or immunologic binds. Most of IgA disappeared after a long term (4-5 days) of the washing. Spots of the remaining fluorescent seemed to reside in the gaps of the keratinized layer in the sections of Eosin staining. Albumin behaved in the same manner as in the IgA. 3. The saliva labelled by the fluorescence infiltrated into the keratinized layer of the mucosa after 24 hours of the incubation dipping of the layer side. The fluorescence was weakly spread over the keratinized layer with several strong spots. 4. The extract of the hard palate, which rarely contained the submucosal tissue, and the secreted saliva showed the similar immunoelectrophoretic profiles, which were distinct from those of serum. These results support that IgA in the keratinized layer originated from the secreted saliva. The idea that the naturally occurring antibodies in the oral mucosa attributed to IgA in the keratinized layer was unsuitable because of the comparison of the proportions of the titre to its content in the tissue extract and to that of the secreted saliva.

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