Observation of the Effect of Methohexital-Na (Brevital^[○!R] Sodium), an Intravenous Anesthetic, on the Central Nervous, the Respiration and the Cardiovascular System
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- Kuroki Kayoko
- Department of Dental Pharmacology Kyushu Dental College
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- Murakami Yuji
- Department of Dental Pharmacology Kyushu Dental College
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- Yoshimura Taiji
- Department of Dental Pharmacology Kyushu Dental College
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- Nishi Masakatsu
- First Department of Oral Surgery Kyushu Dental College
Bibliographic Information
- Other Title
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- 静脈麻酔剤メトヘキシタール・ナトリウムの麻酔作用ならびに呼吸血圧作用
- ジョウミャク マスイザイ メトヘキシタール ナトリウム ノ マスイ サヨウ ナ
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Abstract
Examinations of the effect of Methohexital-Na were made in rabbits and its anesthetic action was observed by Girndt-Magnus's method. The action on the respiration and blood pressure were recorded by a tambour and a mercury manometer. The results were as follows. 1. Methohexital-Na did not cause narcosis in the dose of 1 mg/kg, but in the dose of 5 mg/kg deep anesthesia was obtained. The duration of anesthesia lasted only 2 to 3 minutes. After 6 to 8 minutes, the animal recovered consciousness. 2. In the dose of 5 mg/kg, the respiration and blood pressure were arrested sufficiently. But these depressions soon passed away. After 4 to 5 minutes, the animal recovered consciousness. 3. Narcotic effect of Methohexital-Na was influenced to some extent by its injection speed. When injection was given speedily, narcosis became deeper and depressions increased. But there was no distinct difference whether the injection speed was in 10 or in 60 seconds. Even injection in 10 seconds brought about above mentioned symptoms but it lasted only 10 to 20 seconds. In view of the foregoings, it is considered that Methohexital-Na is an adequate anesthetic without any apparent side-effect in narcotic dose (5 mg/kg) injected in the speed of about 30 seconds.
Journal
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- The Journal of the Kyushu Dental Society
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The Journal of the Kyushu Dental Society 32 (3), 298-304, 1978
KYUSHU DENTAL SOCIETY
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Details 詳細情報について
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- CRID
- 1390001206349338624
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- NII Article ID
- 110003002794
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- NII Book ID
- AN00054335
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- ISSN
- 18808719
- 03686833
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- NDL BIB ID
- 1961049
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed