急性四エチル鉛中毒の実験　Ｉ　　四エチル鉛がラットの睡眠‐覚せいサイクルに及ぼす影響

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書誌事項

タイトル別名
  • Studies on Tetraethyl Lead Intoxication
  • キュウセイ シ エチル ナマリ チュウドク ノ ジッケンテキ ケンキュウ 1
  • 第1報 四エチル鉛がラットの睡眠-覚醒サイクルに及ぼす影響について

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説明

The authors examined acute intoxication from tetraethyl lead (TEL) in the central nervous system of rats by means of a polygraph.<br>Twenty-five white male Wistar rats, weighing between 295 and 310g each were examined. Under Nembutal anesthesia bipolar electrodes were implanted on the surface of the cortex between the frontal and occipital lobes of the left and right hemispheres, on the bilateral canthi and on the neck muscles. The animals were divided into five groups of five rats each. The five groups were given TEL in doses of 0.0mg, 10mg, 20mg, 40mg and 80mg per kg body weight respectively. Observations began two weeks after the operation and were by means of a polygraph. Each observation session lasted for 24 hours once before the TEL injection (from 3 to 5 days before) for all rats; and then daily, from immediately after the injection until death for the 20mg, 40mg, 80mg groups; and on days 1, 2, 3, 4, 5, 6, 9, 11, 15, 19, 25 and 30 following the injections for 0.0mg (control) and 10mg groups.<br>The polygram included readings for electroencephalogram (EEG), electrooculogram (EOG), electromyogram (EMG) and respiratory movement (RM), which were simultaneously recorded with a San-Ei 9 or 13-channel electropolygraph.<br>The following results were obtained;<br>1. All rats given 20mg, 40mg and 80mg/kg of TEL died, the period before the appearance of toxic symptoms decreased, the greater the amount of TEL administered. The TEL 10mg/kg group survived and toxic symptoms did not appear.<br>2. After the TEL injection, body weight continued to decrease until death in the following order; 20mg, 40mg and 80mg/kg groups. In the 10mg/kg group, it decreased for eight days after the injection of TEL, but thereafter it remained stable.<br>3. Concerning the sleeping-waking cycle obtained from the polygraph after the injection of TEL, the amount of slow wave sleep (SS) and paradoxical sleep (PS) both decreased markedly until death. The decrease in SS and PS was found to be greater in the following order; 80mg, 40mg, and 20mg/kg groups. In the 10mg/kg group, both SS and PS decreased for five days after the injection of TEL, after which they reverted to normal levels.<br>From the above results, it can be said that the changes in sleeping-waking cycles correlate directly to the extent of the poisoning, and such as poisoning can be seen creating a disturbance in the central nervous system.

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