逐次近似SPECT再構成法の<sup>123</sup>I-IMP局所脳血流量定量への応用─最適な再構成法と前処理フィルタの遮断周波数に関する検討─

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タイトル別名
  • Application of N-Isopropyl-p-[<sup>123</sup>I] Iodoamphetamine Quantification of Regional Cerebral Blood Flow Using Iterative Reconstruction Methods: Selection of the Optimal Reconstruction Method and Optimization of the Cutoff Frequency of the Preprocessing Filter
  • 臨床技術 逐次近似SPECT再構成法の¹²³I-IMP局所脳血流量定量への応用 : 最適な再構成法と前処理フィルタの遮断周波数に関する検討
  • リンショウ ギジュツ チクジ キンジ SPECT サイコウセイホウ ノ ¹ ² ³ I-IMP キョクショ ノウ ケツ リュウリョウ テイリョウ エ ノ オウヨウ : サイテキ ナ サイコウセイホウ ト マエショリ フィルタ ノ シャダン シュウハスウ ニ カンスル ケントウ
  • Application of N-Isopropyl-p-[123I] Iodoamphetamine Quantification of Regional Cerebral Blood Flow Using Iterative Reconstruction Methods: Selection of the Optimal Reconstruction Method and Optimization of the Cutoff Frequency of the Preprocessing Filter

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In cerebral blood flow tests using N-Isopropyl-p-[123I] Iodoamphetamine 123I-IMP, quantitative results of greater accuracy than possible using the autoradiography (ARG) method can be obtained with attenuation and scatter correction and image reconstruction by filtered back projection (FBP). However, the cutoff frequency of the preprocessing Butterworth filter affects the quantitative value; hence, we sought an optimal cutoff frequency, derived from the correlation between the FBP method and Xenon-enhanced computed tomography (XeCT)/cerebral blood flow (CBF). In this study, we reconstructed images using ordered subsets expectation maximization (OSEM), a method of successive approximation which has recently come into wide use, and also three-dimensional (3D)-OSEM, a method by which the resolution can be corrected with the addition of collimator broad correction, to examine the effects on the regional cerebral blood flow (rCBF) quantitative value of changing the cutoff frequency, and to determine whether successive approximation is applicable to cerebral blood flow quantification. Our results showed that quantification of greater accuracy was obtained with reconstruction employing the 3D-OSEM method and using a cutoff frequency set near 0.75–0.85 cycles/cm, which is higher than the frequency used in image reconstruction by the ordinary FBP method.

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