Influence of High-definition Multileaf Collimator for Three-dimensional Conformal Radiotherapy and Intensity-modulated Radiotherapy of Prostate Cancer

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  • Fujimoto Sachie
    Hiroshima Heiwa Clinic, State of the Art Treatment Center
  • Ono Kaoru
    Hiroshima Heiwa Clinic, State of the Art Treatment Center
  • Furukawa Kengo
    Hiroshima Heiwa Clinic, State of the Art Treatment Center
  • Kudo Tsuyoshi
    Hiroshima Heiwa Clinic, State of the Art Treatment Center
  • Akagi Yukio
    Hiroshima Heiwa Clinic, State of the Art Treatment Center
  • Koyama Tadashi
    Hiroshima Heiwa Clinic, State of the Art Treatment Center
  • Hirokawa Yutaka
    Hiroshima Heiwa Clinic, State of the Art Treatment Center
  • Kawai Shintarou
    Department of Radiotherapy, Clinical Support Department, Hiroshima University Hospital
  • Nakashima Takeo
    Department of Radiotherapy, Clinical Support Department, Hiroshima University Hospital

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Other Title
  • 前立腺3DCRTおよびIMRTにおける High-definition Multileaf Collimatorの影響
  • ゼンリツセン 3DCRT オヨビ IMRT ニ オケル High-definition Multileaf Collimator ノ エイキョウ

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The focus of this work is to evaluate the dosimetric impact of treatment planning for three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) of prostate cancer using Varian/BrainLAB 120-leaf high-definition multileaf collimator (HD120 MLC) with 2.5 mm leaf width and Varian 120-leaf millennium multileaf collimator (M120 MLC) with 5 mm leaf width. We measured the leaf transmission and dosimetric leaf gap (DLG) of two multileaf collimator (MLC) systems using Farmer ionization chamber. The dosimetric impact of treatment planning for 3DCRT and IMRT of prostate cancer for ten clinical cases using two MLC systems was evaluated quantitatively. 3DCRT was divided to 3DCRTmiddle as fitting at middle of leaf tip and 3DCRToutside as fitting at outside of leaf tip. The leaf transmission factor and DLG of HD120 MLC for 6 and 10 MV X-ray decreased by 0.2% and 1 mm, respectively, compared to M120 MLC. The mean conformity index of PTV of treatment planning for prostate 3DCRTmiddle, 3DCRToutside, and IMRT decreased by 0.9%, 6.6%, and 0.9% and the mean homogeneity index increased 2.3%, 13.0%, and 4.2%, respectively. The mean V20, V40, and V65 decreased by 2.4%, 6.6%, and 4.5% for bladder and 3.3%, 6.1%, and 5.9% for rectum, respectively. The results of this work demonstrated that the dose conformity of PTV improved and the dose of bladder and rectum decreased for 3DCRT and IMRT of prostate cancer using HD120 MLC compared to M120 MLC, because of reduction of leaf width, leaf transmission, and rounded leaf end transmission.

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