Comparison of Diffusion Tensor Imaging-Derived Fractional Anisotropy in Multiple Centers for Identical Human Subjects

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  • Saotome Kousaku
    Center for Cybernics Research, University of Tsukuba
  • Ishimori Yoshiyuki
    Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences
  • Isobe, Tomonori
    Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Satou Eisuke
    School of Allied Health Sciences, Kitasato University
  • Shinoda Kazuya
    Department of Radiological Technology, Tsukuba Medical Center Hospital
  • Ookubo Jun
    Department of Radiological Technology, Tsukuba Medical Center Hospital
  • Hirano Yuuji
    Department of Radiology, Tsukuba University Hospital
  • Oosuka Satoru
    Department of Neurosurgery, University of Tsukuba
  • Matsushita Akira
    Center for Cybernics Research, University of Tsukuba Department of Neurosurgery, University of Tsukuba
  • Miyamoto Katsumi
    Department of Radiological Technology, Tsukuba Medical Center Hospital
  • Sankai Yoshiyuki
    Graduate School of Systems and Information Engineering, University of Tsukuba

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Other Title
  • 複数機種において同一被験者群を用いて得られた Fractional Anisotropy値の比較
  • フクスウ キシュ ニ オイテ ドウイツ ヒケンシャグン オ モチイテ エラレタ Fractional Anisotropyチ ノ ヒカク

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Description

The fractional anisotropy (FA) is calculated by using diffusion tensor imaging (DTI) with multiple motion probing gradients (MPG). While FA has become a widely used tool to detect moderate changes in water diffusion in brain tissue, the measured value is sensitive to scan parameters (e.g. MPG-direction, signal to noise ratio, etc.). Therefore, it is paramount to address the reproducibility of DTI measurements among multiple centers. The purpose of this study was to assess the inter-center variability of FA. We studied five healthy volunteers who underwent DTI brain scanning three times at three different centers (I–III), each with a 1.5 T scanner having a different MPG-schema. Then, we compared the FA and eigenvalue from the three centers measured in seven brain regions: splenium of corpus callosum (CCs), genu of corpus callosum (CCg), putamen, posterior limb of internal capsule, cerebral peduncle, optic radiation, and middle cerebellar peduncle. At the CCs and CCg, there was a statistical difference (p<0.05) between center Iand center IIfor the same MPG-directions. Furthermore, at CCs and CCg, there was a statistical difference (p<0.05) between center II and center III for different MPG-directions. Conversely, no statistical differences were found between center I and center III for the different MPG-directions for all regions. These results indicate that the FA value was affected by the MPG-schema as well as by the MPG-directions.

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