The Detectability of Iterative CT Reconstruction for Low-contrast Lesions in Hyperacute Cerebral Infarction: Assessment with Newly Developed Dedicated Head Phantoms

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  • Nishimura Kazuaki
    Department of Radiology, Hirakata City Hospital
  • Tanaka Chikako
    Division of Radiology, Department of Medical Technology, Osaka University Hospital
  • Fukao Mari
    Division of Radiology, Department of Medical Technology, Osaka University Hospital
  • Ueguchi Takashi
    Center for Information and Neural Networks, National Institute of Information and Communications Technology Graduate School of Frontier Biosciences, Osaka University Graduate School of Medicine, Osaka University
  • Nshizawa Mitsuo
    Department of Radiology, Osaka Medical College

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Other Title
  • 逐次近似応用CT 再構成を用いた低吸収域の検出能評価―超急性期脳梗塞評価用ファントムの開発および解析―
  • チクジ キンジ オウヨウ CT サイコウセイ オ モチイタ テイキュウシュウイキ ノ ケンシュツノウ ヒョウカ : チョウキュウセイキ ノウ コウソク ヒョウカヨウ ファントム ノ カイハツ オヨビ カイセキ

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Abstract

Iterative reconstruction techniques, such as adaptive statistical iterative reconstruction (ASiR), improve the contrast-to-noise ratio of computed tomography (CT) images; however, underlying anatomical structures may nevertheless hamper detectability of low-contrast areas in clinical situations, despite using such a technique. We therefore conducted a phantom study to investigate the efficacy of ASiR in improving the detectability of low-contrast areas in the presence of brain anatomical structures. We developed dedicated head phantoms simulating hyperacute cerebral infarction and confirmed that their CT numbers were sufficiently reproducible and that observer performance in detecting low-contrast areas using these phantoms more closely resembled that in clinical situations than that using a simple phantom. The efficacy of ASiR in improving low-contrast detectability was evaluated via receiver operating characteristics analysis. The mean area under the curve (AUC) values at ASiR blend rates of 0%, 30%, 60%, and 100% were 0.57, 0.57, 0.59, and 0.59 at 200 mA; 0.83, 0.84, 0.84, and 0.90 at 500 mA; and 0.79, 0.77, 0.76, and 0.79 at 800 mA, respectively. No significant differences were noted in AUC values among ASiR blend rates at any mA setting, suggesting that ASiR does not improve the detectability of subtle low-contrast lesions seen in hyperacute cerebral infarction in clinical situations.

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