亜硝酸ナトリウムのマウス心室筋活動電位の応答性に対する影響について

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  • Effects of sodium nitrite on the action potential responses of ventricular muscles in mice.
  • アショウサン ナトリウム ノ マウス シンシツキン カツドウ デンイ ノ オウ

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The effects of sodium nitrite (NaNO2) were tested on strips of the cardiac muscle prepared from the ventricles of male ICR mice 4, 16 and 78 week-old. The strips were immersed in Ringer solution containing 0.01% NaNO2 and action potentials evoked by repetitive electrical stimulation were recorded by means of conventional microelectrode recording. The results obtained were as follows.<br>1) In 4 week-old mice: No detectable difference was observed in the action potential responses evoked by 5Hz stimulation at 1.3V in the control (before treatment), treatment (with NaNO2) and recovery periods. At 10Hz, action potentials were evoked once every 2 stimuli in the control and once every stimuli in the treatment. At 20Hz, action potentials were evoked every 3rd stimulus in the control and once every 2nd stimulus in the treatment. The responses thus elevated did not return to the control level during the periods of recovery after wash out of the drug.<br>2) In 16 week-old mice: The responses were tested at 1.0V and found similar to that of the 4 week-old animals. However, they recovered appreciably during the wash out period.<br>3) In 78 week-old mice: Action potentials were normally evoked by 1.5V stimuli at 5Hz in the same way as 1) and 2), whereas 2.8V were needed at 10 and 20Hz in the treatment with the drug. The responses was elevated in the treatment, as in 1) and 2), and somewhat reduced in the wash out period.

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