赤血球変形能と性，年齢，血圧，肥満，血清脂質，飲酒および喫煙習慣との関連

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  • Red Blood Cell Deformability in Relation to Gender, Age, Blood Pressure, Obesity, Serum Lipids, Alcohol Consumption and Smoking.
  • セッケッキュウ ヘンケイノウ ト セイ ネンレイ ケツアツ ヒマン ケッセイ シシツ インシュ オヨビ キツエン シュウカン ト ノ カンレン

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Objectives: To determine the effects of environmental factors on abnormalities in red blood cell deformability (RBCD), which may play an important role in the development of cardiovascular diseases, a cross-sectional epidemiological study was conducted in healthy subjects.<br>Method: The subjects were 350 males (mean age 52.7±10.3 SD) and 364 females (52.6±10.4) who participated in a health check program in the town of Akabane, Japan, in 1995-1998. Blood and serum were obtained to determine the values of RBCD and TP, TG, TCHOL, and HDLC. The inverse of RBCD (RBCDI, ms-1) was used as an indicator of RBCD. The subjects were also investigated for drinking and smoking habits, BMI, and SBP. Males and females were stratified into tertiles for each variable except drinking and smoking. For those exceptions, male subjects were stratified into three groups according to alcohol consumption (non-drinkers, moderate drinkers (up to 27ml pure ethanol per day), and habitual drinkers (28ml or more per day)) and according to tobacco use (non-smokers, mild smokers (equal or fewer than 20 cigarettes per day), and heavy smokers, (more than 20)). Each stratum was further divided into two groups according to age (younger, <50 years; older, ≥50 years).<br>Results: The mean value of RBCDI was significantly higher in males (1.041±0.135 SD) than in females (1.013±0.113). RBCDI declined with age in both genders. In analyses of variance, the averages of RBCDI decreased as TP increased in all ages and in both genders and as TCHOL increased in older males. With regard to alcohol consumption, the averages of RBCDI were the highest in moderate drinkers in younger males. Multiple linear regression analyses showed negative correlations between RBCDI values and age, TP or TCHOL values, and showed positive correlations between RBCDI values and BMI in males as well as negative correlations between RBCDI values and age and TP in females. When alcohol drinking was entered into the model, the statistical significance between TCHOL and RBCDI disappeared in males. No apparent relations between smoking habit and levels of SBP and TG to RBCDI were found.<br>Conclusions: RBCDI was higher in males than in females and higher in the younger group than in the older group. This study suggested that TCHOL may lower RBCDI and moderate drinking may improve it. Further epidemiological study is required to clarify these relationships.

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