食用色素の人培養細胞における細胞遺伝学的影響

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  • Cytogenetic effect of food dyes on cultured human cells.
  • 食用色素の人培養細胞における細胞遺伝学的影響〔英文〕
  • ショクヨウ シキソ ノ ジン バイヨウ サイボウ ニ オケル サイボウ イデン

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Cytogenetic effects of 10 kinds of food dyes were studied on human leucocytes and fibroblasts in vitro. Among the dyes tested phloxine induced structural chromosome aberrations involving mostly gaps and breaks of chromatid type, whereas the other dyes did not induce aberrations within the limit of the present experiments. Three xanthin-dyes, erythrosine, phloxine, and rose bengale, were found to be strong inhibitors of DNA-synthesis, showing a significantly reduced thymidine incorporation, while the remaining 7 agents including 5 azodyes showed moderate or no inhibitions.

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